Cocaine addiction: Clues from Drosophila on drugs
نویسنده
چکیده
Recent studies have shown that the fruitfly Drosophila exhibits behavioral sensitization in response to repeated exposure to cocaine; the exploitation of this genetically tractable model system for studying cocaine addiction is already providing new clues that may help understand the process of drug addiction in man.
منابع مشابه
Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.
In the last decade, the fruit fly Drosophila melanogaster, highly accessible to genetic, behavioral and molecular analyses, has been introduced as a novel model organism to help decipher the complex genetic, neurochemical, and neuroanatomical underpinnings of behaviors induced by drugs of abuse. Here we review these data, focusing specifically on cocaine-related behaviors. Several of cocaine's ...
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BACKGROUND Sensitization to psychostimulant drugs of abuse is thought to be an important aspect of human addiction, yet how it develops is still unclear. The development of sensitization to cocaine in the fruit fly Drosophila melanogaster is strikingly similar to that observed in vertebrates. By taking advantage of the powerful genetic approaches that are possible in Drosophila, we are able to ...
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عنوان ژورنال:
- Current Biology
دوره 9 شماره
صفحات -
تاریخ انتشار 1999